Studies on intravenous glucose tolerance curve. 2. Experiments with rabbits.

There are many studies on change in blood sugar level after intravenous administration of glucose (Tunbridge & Allibone, 1940; Greville, 1943; Nonobe, 1952), and the majority of them support the conclusion that blood sugar level decreases in the way of monomolecular reaction (Fishberg, 1930), that is, the change is represented by an exponential curve expressed by a formula log y=-kt+c (y, blood sugar level; t, time; k and c, constant). On the other hand, it has also been reported since early, that there are cases in which the change is represented by an atypical curve to which the above mentioned formula can not be applied.However, its significance and the mechanism of its development do not have drawn so much attention of workers.Previously, experiments on blood sugar curve with adult and young dogs were carried out and it was found that cases of the atypical curve are not so rare and that the type of the curve may depend on the state of some equilibrium of the metabolism, especially the endocrinological equilibrium (Takeuchi et al., 1957). In the present experiments with rabbits was found out an interesting fact concerning the atypical blood sugar curve. Below are given the description of these experiments.